DeepTCM1.0: A Multi-Expert AI Agent for Deciphering Mechanisms of Chinese Herbal Formulae Based on General Large Language Models
Mirrored from arXiv — NLP / Computation & Language for archival readability. Support the source by reading on the original site.
Computer Science > Computation and Language
Title:DeepTCM1.0: A Multi-Expert AI Agent for Deciphering Mechanisms of Chinese Herbal Formulae Based on General Large Language Models
Abstract:Background: Mechanistic elucidation of traditional Chinese medicine (TCM) compound formulas remains a central challenge in the modernization of TCM. Conventional approaches, including data mining and network pharmacology, are insufficient for achieving deep integration between classical TCM theory and modern scientific research. In addition, direct question-answering using general-purpose artificial intelligence large language models is limited by inadequate adaptation to TCM theoretical frameworks and susceptibility to reasoning hallucinations. Consequently, there is an urgent need to develop intelligent analytical methods aligned with the holistic principles of TCM. Objective: To establish a multi-expert intelligent agent framework integrating classical TCM theory with modern life sciences, thereby enabling systematic and interpretable mechanistic analysis of TCM compound formulas, with Guizhi Decoction serving as a representative validation case. Methods: The DeepTCM1.0 framework was constructed based on the general-purpose large language model DeepSeek V3.2. It adopts a three-tier collaborative architecture and a three-round iterative quality-control workflow, simulating the collaborative analytical process of 11 interdisciplinary intelligent agents. The framework was applied to the mechanistic interpretation of Guizhi Decoction from the dual perspectives of classical traditional Chinese medicine theory and modern scientific research. Framework performance was comprehensively evaluated through double-blind five-dimensional scoring, intraclass correlation coefficient (ICC) reliability testing, Mann-Whitney U tests, and effect size analysis. The evaluation employed four independent large language models as evaluators, each conducting five rounds of repeated scoring on five anonymized reports, resulting in a total of 100 independent scoring assessments.
| Subjects: | Computation and Language (cs.CL); Artificial Intelligence (cs.AI) |
| Cite as: | arXiv:2608.18103 [cs.CL] |
| (or arXiv:2608.18103v1 [cs.CL] for this version) | |
| https://doi.org/10.48550/arXiv.2608.18103
arXiv-issued DOI via DataCite
|
Access Paper:
- View PDF
References & Citations
Bookmark
Bibliographic and Citation Tools
Code, Data and Media Associated with this Article
Demos
Recommenders and Search Tools
arXivLabs: experimental projects with community collaborators
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website.
Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them.
Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
More from arXiv — NLP / Computation & Language
-
Recipes for Steering and Scaling LLMs via Sampling
Aug 28
-
Can a Model Catch Its Own Hallucinations for Free?: Label-Free Doubt Signals Hold Their Own Against a Labelled Dataset for Abstention
Aug 28
-
FIRSTPASS: A Multi-Domain, Multi-Round Peer Review Dataset Grounded in Real Editorial Outcomes
Aug 28
-
Interpretable, Fairly Evaluated Automated L2 Speaking Assessment that Beats the Single-Human Ceiling and Why Pause Encoding Does Not Change LLM Fluency Scores
Aug 28
Discussion (0)
Sign in to join the discussion. Free account, 30 seconds — email code or GitHub.
Sign in →No comments yet. Sign in and be the first to say something.