Title:Using Human-LLM Disagreement to Improve Checklist-Based Quality Appraisal

Abstract:Systematic reviews rely on quality appraisal of included studies, a process that is time-consuming and sensitive to ambiguity in checklist criteria. Although large language models (LLMs) offer opportunities to support these tasks, appraisal checklists are typically treated as fixed inputs, and it remains unclear how their design affects agreement with expert judgments. Therefore, we investigate (1) whether LLMs can approximate human judgments in checklist-based appraisal and (2) whether patterns of human-LLM disagreement can be used to identify and improve ambiguous checklist items. Using the Guidelines for Reporting on Latent Trajectory Studies (GRoLTS) checklist, we compare LLM-generated assessments with expert annotations across three research topics and two checklist versions. Agreement is assessed using item-level accuracy, chance-corrected agreement, and preservation of study-level rank ordering.
We find that performance varies substantially across checklist items, with ambiguous and conditional criteria producing the greatest disagreement. Revising these items improves both raw and chance-corrected agreement. Although item-level misclassifications persist, LLM-generated scores often preserve the relative ranking of studies when high-agreement items are retained. These results indicate that reliable LLM-assisted appraisal depends not only on model choice but also on checklist design. The findings suggest that analyzing human-LLM disagreement can help identify problematic checklist items and support the iterative improvement of research synthesis workflows.

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